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Helsinki PAS Project

CLINICAL RESEARCH ON SPINAL CORD INJURY REHABILITATION

2023

Haakana P, Holopainen K, Nätkynmäki A, Kirveskari E, Tarvainen MP, Shulga A. The effect of paired associative stimulation with a high-intensity cortical component and a high-frequency peripheral component on heart rate and heart rate variability in healthy subjects. Front Rehabil Sci. 2023 Jul 26;4:1200958. doi: 10.3389/fresc.2023.1200958.

2022

Pohjonen M, Nyman A-L, Kirveskari E, Arokoski J, Shulga A. Optimal peripheral nerve stimulation intensity for paired associative stimulation with high-frequency peripheral component in healthy subjects. Sci Rep. 2022 Jul 21;12(1):12466. doi: 10.1038/s41598-022-16811-1.

Vanhanen J, Parkkonen L, Mäkelä JP, Tolmacheva A, Shulga A, Rodionov A, Kirveskari E. Effect of long-term paired associative stimulation on the modulation of cortical sensorimotor oscillations after spinal cord injury. Spinal Cord Ser Cases 2022 Apr 5;8(1):38. doi: 10.1038/s41394-022-00506-w

2021

Vaalto S, Nyman A-L, Shulga A. Analgesic effect of paired associative stimulation in a tetraplegic patient with severe drug-resistant neuropathic pain: a case report. Scand J Pain May 21, 2021, https://doi.org/10.1515/sjpain-2021-0012

Shulga A, Lioumis P, Kirveskari E, Savolainen S, Mäkelä J. A novel paired associative stimulation protocol with a high‐frequency peripheral component: A review on results in spinal cord injury rehabilitation. European J. Neurosci; 3/2021, https://doi.org/10.1111/ejn.15191

Pohjonen M, Savolainen S, Arokoski J, Shulga A. Omitting TMS component from paired associative stimulation with high-frequency PNS: A case series of tetraplegic patients. Clin Neurophys Practice; 2021; 6. doi:10.1016/j.cnp.2021.01.004

2020

Mezes M, Havu R, Tolmacheva A, Lioumis P, Mäkelä JP, Shulga A. The impact of TMS and PNS frequencies on MEP potentiation in PAS with high-frequency peripheral component. PLoS One. 2020;15(5):e0233999. Published 2020 May 29. doi:10.1371/journal.pone.0233999

Rodionov A, Savolainen S, Kirveskari E, Makela JP, Shulga A. Effects of Long-Term Paired Associative Stimulation on Strength of Leg Muscles and Walking in Chronic Tetraplegia: A Proof-of-Concept Pilot Study. Front. Neurol., 20 May 2020, doi:10.3389/fneur.2020.00397

Shulga A, Savolainen S, Kirveskari E, Mäkelä JP. Enabling and promoting walking rehabilitation by paired associative stimulation after incomplete paraplegia: a case report. Spinal Cord Ser Cases. 2020;6(1):72. Published 2020 Aug 13. doi:10.1038/s41394-020-0320-7

2019

Tolmacheva A, Mäkelä JP, Shulga A. Increasing the frequency of peripheral component in paired associative stimulation strengthens its efficacy. Sci Rep. 2019;9(1):3849. Published 2019 Mar 7. doi:10.1038/s41598-019-40474-0

Tolmacheva A, Savolainen S, Kirveskari E, Brandstack N, Mäkelä JP, Shulga A. Paired associative stimulation improves hand function after non-traumatic spinal cord injury: A case series. Clin Neurophysiol Pract. 2019;4:178-183. Published 2019 Aug 13. doi:10.1016/j.cnp.2019.07.002

Rodionov A, Savolainen S, Kirveskari E, Mäkelä JP, Shulga A. Restoration of hand function with long-term paired associative stimulation after chronic incomplete tetraplegia: a case study. Spinal Cord Ser Cases. 2019;5:81. Published 2019 Oct 1. doi:10.1038/s41394-019-0225-5

Rodionov A, Tolmacheva A, Kirveskari E, Mäkelä JP, Shulga A. The use of electronic coil location control for focal magnetic stimulation at the cervical level. 2019 Dec 1;328:1084 J Neurosci Methods. doi: 10.1016/j.jneumeth.2019.108444

2017

Tolmacheva A, Savolainen S, Kirveskari E, et al. Long-Term Paired Associative Stimulation Enhances Motor Output of the Tetraplegic Hand. J Neurotrauma. 2017;34(18):2668-2674. doi:10.1089/neu.2017.4996

2016

Shulga A, Lioumis P, Zubareva A, Brandstack N, Kirveskari E, Kuusela L, Savolainen S, Ylinen A, Mäkelä JP. Long-term paired associative stimulation can restore voluntary control over paralyzed muscles in incomplete chronic spinal cord injury patients. Spinal Cord Ser Cases 2, 16016 (2016). https://doi.org/10.1038/scsandc.2016.16

Shulga A, Zubareva A, Lioumis P, Mäkelä JP. Paired Associative Stimulation with High-Frequency Peripheral Component Leads to Enhancement of Corticospinal Transmission at Wide Range of Interstimulus Intervals. Front Hum Neurosci. 2016;10:470. Published 2016 Sep 23. doi:10.3389/fnhum.2016.00470.

2015

Shulga A, Lioumis P, Kirveskari E, Savolainen S, Mäkelä J, Ylinen A. The use of F-response in defining interstimulus intervals appropriate for LTP-like plasticity induction in lower limb spinal paired associative stimulation. J Neurosci Methods. 2015; Mar 15;242:112-7. doi: 0.1016/j.jneumeth.2015.01.012

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